Important Warning: Editing an actively open file can corrupt it. This guide assumes you are making a copy, editing it offline (while the program is closed), and then replacing it.
On Windows systems with SPSS installed, you can control the active SPSS instance from Python or PowerShell, instructing it to edit its own active file. How To Edit Active Sav File
Watch these tutorials for visual walkthroughs on editing save files for various games: Important Warning: Editing an actively open file can
If by “active” you meant the file is currently in use by SPSS and you want to change values on the fly, use Syntax + SAVE – that’s the standard, safe method. Disable cloud sync or pause network before editing