The most successful fix for this error, especially when it occurs immediately after launching a game, is to sync your trophies with the PlayStation Network. Open the Trophies application on your Vita. Ensure you are connected to the internet.
If you own the original OLED model (PCH-1000), the internal system storage is minimal. The Vita sometimes "loses" the memory card during sleep mode. ps vita c127380 fixed
error on the PS Vita is a common issue typically related to trophy synchronization conflicting plugins The most successful fix for this error, especially
If none of the above works, the memory card may have physically failed (dead NAND chips). In that case: Press and hold the power button until your PS Vita turns off